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Margo Brinton

Professor    
Education

Ph.D. Microbiology/Virology,University of Pennsylvania, Philadelphia, 1972

Specializations

Virus-Host Molecular Interactions, Immunity & Molecular Genetics

My laboratory conducts research in the following areas: (1) Molecular and cellular basis of virus-host interactions and host anti-viral responses of West Nile virus and simian hemorrhagic fever virus; (2) Regulation of West Nile virus replication; (3) Functional analysis of flavivirus genetic resistance.

Biography
Publications
  1. Pulit-Penaloza JA, Scherbik SV, Brinton MA. Type 1 IFN-independent activation of a subset of interferon stimulated genes in West Nile virus Eg101-infected mouse cells. Virology. 2012 Apr 10;425(2):82-94.
  2. Pulit-Penaloza JA, Scherbik SV, Brinton MA. Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation. Virology. 012 Apr 10;425(2):71-81.
  3. Courtney SC, Scherbik SV, Stockman BM, Brinton MA.  West nile virus infections suppress early viral RNA synthesis and avoid inducing the cell stress granule response. J Virol. 2012 Apr;86(7):3647-57.
  4. Elbahesh H, Scherbik SV, Brinton MA. West Nile virus infection does not induce PKR activation in rodent cells.  Virology. 2011 Dec 5;421(1):51-60.
  5. Bigham AW, Buckingham KJ, Husain S, Emond MJ, Bofferding KM, Gildersleeve H, Rutherford A, Astakhova NM, Perelygin AA, Busch MP, Murray KO, Sejvar JJ, Green S, Kriesel J, Brinton MA, Bamshad M. Host genetic risk factors for West Nile virus infection and disease progression. PLoS One. 2011;6(9):e24745.
  6. Barkhash AV, Perelygin AA, Babenko VN, Myasnikova NG, Pilipenko PI, Romaschenko AG, Voevoda MI, Brinton MA. Variability in the 2′-5′-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. J Infect Dis. 2010 Dec 15;202(12):1813-8.
  7. Scherbik SV, Brinton MA. Virus-induced Ca2+ influx extends survival of west nile virus-infected cells. J Virol. 2010 Sep;84(17):8721-31.
  8. Astakhova NM, Perelygin AA, Zharkikh AA, Lear TL, Coleman SJ, MacLeod JN, Brinton MA. Characterization of equine and other vertebrate TLR3, TLR7, and TLR8 genes. Immunogenetics. 2009 Jul;61(7):529-39
  9. Emara MM, Liu H, Davis WG, Brinton MA..  Mutation of mapped TIA-1/TIAR binding sites in the 3′ terminal stem-loop of West Nile virus minus-strand RNA in an infectious clone negatively affects genomic RNA amplification. J Virol. 2008 Nov;82(21):10657-70.
  10. Pulendran B, Miller J, Querec TD, Akondy R, Moseley N, Laur O, Glidewell J, Monson N, Zhu T, Zhu H, Staprans S, Lee D, Brinton MA, Perelygin AA, Vellozzi C, Brachman P Jr, Lalor S, Teuwen D, Eidex RB, Cetron M, Priddy F, del Rio C, Altman J, Ahmed R.A.  Case of yellow fever vaccine–associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes.  J Infect Dis. 2008 Aug 15;198(4):500-7.
  11. Hunt TA, Urbanowski MD, Kakani K, Law LM, Brinton MA, Hobman TC. Interactions between the West Nile virus capsid protein and the host cell-encoded phosphatase inhibitor, I2PP2A. Cell Microbiol. 2007 Nov;9(11):2756-66.
  12. Scherbik SV, Stockman BM, Brinton MA. Differential expression of interferon (IFN) regulatory factors and IFN-stimulated genes at early times after West Nile virus infection of mouse embryo fibroblasts. J Virol. 2007 Nov;81(21):12005-18.
  13. Davis WG, Blackwell JL, Shi PY, Brinton MA. Interaction between the cellular protein eEF1A and the 3′-terminal stem-loop of West Nile virus genomic RNA facilitates viral minus-strand RNA synthesis. J Virol. 2007 Sep;81(18):10172-87.
  14. Emara MM, Brinton MA. Interaction of TIA-1/TIAR with West Nile and dengue virus products in infected cells interferes with stress granule formation and processing body assembly. Proc Natl Acad Sci U S A. 2007 May 22;104(21):9041-6.
  15. Scherbik SV, Paranjape JM, Stockman BM, Silverman RH, Brinton MA.  RNase L plays a role in the antiviral response to West Nile virus. J Virol. 2006, 80(6):2987-99.