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Binghe Wang

Professor    Professor of Medicinal Chemistry & Drug Development    
Education

Ph.D. Medicinal Chemistry, University of Kansas, 1991

Specializations

Drug Design, Targeted Delivery, Molecular Imaging and Diagnostics in Inflammatory and Infectious Diseases, Cancer, and Other Diseases

My laboratory conducts research in the following areas: (1) Drug Design (Medicinal Chemistry) including anti-inflammatory (PDE4 inhibitors), anti-microbial and anti-cancer drugs; (2) Targeted Drug Delivery including receptor mediated and biomarker mediated drug delivery; (3) Molecular Recognition and New Diagnostics including new fluorescent imaging and chemosensors, imaging mass spectrometry, lectin mimics for carbohydrate biomarker recognition; (4) New Organic Reactions including photo-affinity labeling chemistry, link chemistry and new methods for DNA modification.

Biography
Publications
  1. Peng, H.; Cheng, Y.; Dai, C.; Wang, B. A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood. Angew. Chem. Int. Ed., 2011, 50 (41), 9672-9675.
  2. Dai, C.; Cazares, L. H., Wang, L.; Chu, Y.; Wang, S. L.; Troyer, D. A.; Semmes, O. J.; Drake, R. R.; Wang, B. Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen. Chem. Commun.,2011, 47, 10338-10340
  3. Chen, Y. F.; Ni, N.; Li, M.; Xu, P. F.; Wang. B. “Design and Synthesis of New Heterocyclic BCR-Abl Inbitors” Heterocycl. Commun., 2011, 16, 123-136
  4. Cao, J.; Fang, H.; Wang, B.; Ma, C.; Xu, W. Epidermal growth factor receptor as a target for anti-cancer agent design. Anti-Cancer Agents in Medicinal Chemistry 2010, 10(6), 491-503
  5. King-Keller, S.; Li, M.; Smith, A.; Zheng, S.; Kaur, G.; Yang, X.; Wang, B.; Docampo, R. Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas’ disease. Antimicrobial Agents and Chemotherapy 2010, 54(9), 3738-3745
  6. Feng, Y.; Li, M.; Wang, B.; Zheng, Y. G. Discovery and Mechanistic Study of a Class of Protein Arginine Methylation Inhibitors. Journal of Medicinal Chemistry 2010, 53(16), 6028-6039.
  7. Jin, S.; Cheng, Y.; Reid, S.; Li, M.; Wang, B. Carbohydrate recognition by boronolectins, small molecules, and lectins. Medicinal Research Reviews 2010, 30(2), 171-257.
  8. Zhang, Y.; Feng, J.; Liu, C.; Zhang, Lei; Jiao, Jie; Fang, H.; Su, Li; Zhang, X.; Zhang, J.; Li, M.; Wang, B.; Xu, W.  Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors. Bioorg. Med. Chem2010, 18(5), 1761-1772
  9. Chen, W.; Huang, Ying-ju; Gundala, S. R.; Yang, H.; Li, M.; Tai, P. C.; Wang, B.  The first low micromolar SecA inhibitors. Bioorg. Med. Chem. 2010, 18(4), 1617-1625
  10. Du, L.; Ni, N.; Li, M.; Wang, B. A fluorescent hydrogen peroxide probe based on a click’ modified coumarin fluorophore. Tetrahedron Lett. 2010, 51(8), 1152-1154.
  11. Peng, H.; Cheng, Y.; Ni, N.; Li, M.; Choudhary, G.; Chou, H. T.; Lu, C. -D.; Tai, P.C.;Wang, B. Synthesis and Evaluation of New Antagonists of Bacterial Quorum Sensing in Vibrio harveyi. Chem Med Chem 2009,  4(9),  1457-1468.
  12. Ni, N.; Li, M.; Wang, J.; Wang, B.   Inhibitors and antagonists of bacterial quorum sensing. Med. Res. Rev2009, 29(1), 65-124.
  13. Ni, N.; Choudhary, G.; Peng, H.; Li, M.; Chou, H. T.; Lu, C. -D.; Gilbert, E. S.; Wang, B.   Inhibition of quorum sensing in Vibrio harveyi by boronic acids. Chem. Biol. Drug Des.2009,  74(1),  51-56.
  14. Li, M.; Fang, H.; Du, L.; Xia, L.; Wang, B. Computational studies of the binding site of alpha1A-adrenoceptor antagonists. J. Mol. Model2008, 14(10), 957-966.
  15. Ko, K.-C.; Wang, B.; Tai, P. C.; Derby, C. D.  Identification of potent bactericidal compounds produced by escapin, an L-amino acid oxidase in the ink of the sea hare Aplysia californica.  Antimicrob. Agents Chem.  2008, 52(12), 4455-4462.
  16. Zheng, S.; Kaur, G.; Wang, H.; Li, M.; Macnaughtan, M.; Yang, X.; Reid, S.; Prestegard, J.; Wang, B.; Ke, H..  Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors. J. Med. Chem. 2008,  51(24), 7673-7688.
  17. Fang, H.; Kaur, Gurpreet; Wang, B. Functional group approaches to prodrugs: functional groups in peptides. Biotechnology: Pharmaceutical Aspects 2007, 5(Pt. 2, Prodrugs: Challenges and Rewards, Part 2), 265-288.
  18. Li, M.; Ni, N.; Chou, H. T.; Lu, C. -D.; Tai, P. C.; Wang, B.   Structure-based discovery and experimental verification of novel Al-2 quorum sensing inhibitors against Vibrio harveyi.    Chem Med Chem 2008,  3(8),  1242-1249.
  19. Ni, N.; Chou, H. T.; Wang, J.; Li, M.; Lu, C. -D.; Tai, P.C.; Wang, B.   Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi. Biochem. Bioph. Res. Co. 2008,  369(2),  590-594.
  20. Ni, N.; Choudhary, G.; Li, M.; Wang, B. Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi. Bioorg. Med. Chem. Lett. 2008, 18(5), 1567-1572.
  21. Lin, N.; Yan, Jun; Huang, Z.; Altier, C.; Li, M.; Carraco, N.; Suyemoto, M.; Johnston, L.; Wang, S.; Wang, Q.; Fang, H.; Caton-Williams, J.; Wang, B. Design and synthesis of boronic-acid-labeled thymidine triphosphate for incorporation into DNA. Nucleic Acids Res. 2007, 35(15), 5274.
  22. Akay, S.; Yang, W.; Wang, J.; Lin, L.; Wang, B. “Synthesis of Dual Fluorescent Benzo[b]thiophene Boronic Acid Derivatives for Sugar Sensing” Chem. Biol. Drug. Design, 2007, 70, 279-289.
  23. Zhang, Y.; Ballard, C.E.; Zheng, S.; Gao, X.; Ko, K.C.; Yang, H.; Brandt, G.; Lou, X.; Tai, P.C.; Lu, C-D.; Wang, B. “Design, synthesis and evaluation of efflux substrate-metal chelator conjugates as potential anti-microbial agents” Bioorg. Med. Chem. Lett.,2007, 17, 707-711.
  24. Yang, W.; Fan, H.; Gao, S.; Gao, X.; Ni, W.; Karnati, V.; Hooks, W.B.; Carson, J.; Weston, B.; Wang, B. “The First Fluorescent Diboronic Acid Sensor Specific for Hepatocellular Carcinoma Cells Expressing Sialyl Lewis X” Chem. Biol2004, 11, 439-448.