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Baozhong Wang

Associate Professor    Georgia State University    ,
Education

Ph.D., Molecular Biology and Biochemistry, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China, 2003.

Biography

Baozhong Wang, Associate Professor at Georgia State University Institute for Biomedical Sciences, is focused on the interaction of viral pathogens with the host immune system. He studies how viral antigens (particularly influenza and HIV antigens) trigger immune responses, with specific emphasis at the crossroads of vaccines and bioengineering through the use of protein nanotechnology and controlled releases in vaccine development.

Baozhong Wang earned his Ph.D in Molecular Biology and Biochemistry from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences in 2003.

Research Interests

Innate and adaptive immune responses are both important for a success protective immunity. My laboratory is focused on understanding how viral pathogens trigger and evade host immune responses, and designs vaccines integrating both innate triggers and immunogens in nanoparticulate platforms as mimicries of virions. We are also interested in the application of the newest bioengineering technology, including nanotechnology and controlled release technology, in vaccine development.

Publications

Selected Publications:

  1. Mohan T., Kim , Berman Z., Wang S., Compans R.W., and Wang B.Z., Co-delivery of GPI-anchored CCL28 and influenza HA in chimeric virus-like particles induce cross-protective immunity against H3N2 viruses. J Control Release. 2016. doi: 10.1016/j.jconrel.2016.05.021. PubMed PMID: 27178810.
  2. Vzorov A., Wang L., Chen J., Wang B.Z., and Compans R.W. Effects of modification of the HIV-1 Env cytoplasmic tail on immunogenicity of VLP vaccines. Virology 2016, 489:141-50.
  3. Feng H., Zhang H., Deng J., Wang L., He Y., Wang S., Seyedtabaei R., Wang Q., Liu L., Galipeau J., Compans R.W. and Wang B.Z. Incorporation of a GPI-anchored engineered cytokine as a molecular adjuvant enhances the immunogenicity of HIV VLPs. Sci Rep 2015: 5: 11856.
  4. Wang L., Hess A., Chang T.Z., Wang Y.C., Champion J.A., Compans R.W. and Wang B.Z. Nanoclusters self-assembled from conformation-stabilized influenza M2e as broadly cross-protective influenza vaccines. Nanomedicine 2014: 10: 473-482.
  5. Wang B.Z., Gill H.S., He C., Ou C., Wang L., Wang Y.C., Feng H., Zhang H., Prausnitz M.R. and Compans R.W. Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity. J Control Release 2014: 178: 1-7.
  6. Ou C., Shi N., Yang Q., Zhang Y., Wu Z., Wang B.Z., Compans R.W. and He C. Protocatechuic acid, a novel active substance against avian influenza virus H9N2 infection. PLoS One 2014: 9: e111004.
  7. Zhang H., Wang L., Compans R.W. and Wang B.Z. Universal influenza vaccines, a dream to be realized soon. Viruses 2014: 6: 1974-1991.
  8. Wang L., Wang Y.C., Feng H., Ahmed T., Compans R.W. and Wang B.Z. Virus-like particles containing the tetrameric ectodomain of influenza matrix protein 2 and flagellin induce heterosubtypic protection in mice. Biomed Res Int 2013: 686549.
  9. Wang L., Zhang H., Compans R.W. and Wang B.Z. Universal influenza vaccines-short review. J Immunol Clin Res 2013: 1: 1003.
  10. Kim M.C., Lee J.S., Kwon Y.M., O E., Lee Y.J., Choi J.G., Wang B.Z., Compans R.W. and Kang S.M. Multiple heterologous M2 extracellular domains presented on virus-like particles confer broader and stronger M2 immunity than live influenza A virus infection. Antiviral Res 2013: 99: 328-335.
  11. Yoo D.G., Kim M.C., Park M.K., Park K.M., Quan F.S., Song J.M., Wee J.J., Wang B.Z., Cho Y.K., Compans R.W. and Kang S.M. Protective effect of ginseng polysaccharides on influenza viral infection. PLoS One 2012: 7: e33678.
  12. Wang B.Z., Gill H.S., Kang S.M., Wang L., Wang Y.C., Vassilieva E.V. and Compans R.W. Enhanced influenza virus-like particle vaccines containing the extracellular domain of matrix protein 2 and a Toll-like receptor ligand. Clin Vaccine Immunol 2012: 19: 1119-1125.
  13. Chaung H.C., Cheng L.T., Hung L.H., Tsai P.C., Skountzou I., Wang B.Z., Compans R.W. and Lien Y.Y. Salmonella flagellin enhances mucosal immunity of avian influenza vaccine in chickens. Vet Microbiol 2012: 157: 69-77.
  14. Weldon W.C., Martin M.P., Zarnitsyn V., Wang B.Z., Koutsonanos D., Skountzou I., Prausnitz M.R. and Compans R.W. Microneedle vaccination with stabilized recombinant influenza virus hemagglutinin induces improved protective immunity. Clin Vaccine Immunol 2011: 18: 647-654.
  15. Vassilieva E.V., Wang B.Z., Vzorov A.N., Wang L., Wang Y.C., Bozja J., Xu R. and Compans R.W. Enhanced mucosal immune responses to HIV virus-like particles containing a membrane-anchored adjuvant. MBio 2011: 2: e00328-00310.
  16. Song J.M., Wang B.Z., Park K.M., Van Rooijen N., Quan F.S., Kim M.C., Jin H.T., Pekosz A., Compans R.W. and Kang S.M. Influenza virus-like particles containing M2 induce broadly cross protective immunity. PLoS One 2011: 6: e14538.
  17. Weldon W.C., Wang B.Z., Martin M.P., Koutsonanos D.G., Skountzou I. and Compans R.W. Enhanced immunogenicity of stabilized trimeric soluble influenza hemagglutinin. PLoS One 2010: 5.
  18. Wang B.Z., Xu R., Quan F.S., Kang S.M., Wang L. and Compans R.W. Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection. PLoS One 2010: 5: e13972.
  19. Skountzou I., Martin Mdel P., Wang B.Z., Ye L., Koutsonanos D., Weldon W., Jacob J. and Compans R.W. Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine. Vaccine 2010: 28: 4103-4112.
  20. Paust S., Gill H.S., Wang B.Z., Flynn M.P., Moseman E.A., Senman B., Szczepanik M., Telenti A., Askenase P.W., Compans R.W. and von Andrian U.H. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol 2010: 11: 1127-1135.
  21. Wang B.Z., Quan F.S., Kang S.M., Bozja J., Skountzou I. and Compans R.W. Incorporation of membrane-anchored flagellin into influenza virus-like particles enhances the breadth of immune responses. J Virol 2008: 82: 11813-11823.
  22. Wang B.Z., Liu W., Kang S.M., Alam M., Huang C., Ye L., Sun Y., Li Y., Kothe D.L., Pushko P., Dokland T., Haynes B.F., Smith G., Hahn B.H. and Compans R.W. Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles. J Virol 2007: 81: 10869-10878.